Here's a literary parable for the 21st century. Lisa Genova, 38, was a health-care-industry consultant in Belmont, Mass., who wanted to be a novelist, but she couldn't get her book published for love or money. She had a Ph.D. in neuroscience from Harvard, but she couldn't get an agent. "I did what you're supposed to do," she says. "I queried literary agents. I went to writers' conferences and tried to network. I e-mailed editors. Nobody wanted it." So Genova paid $450 to a company called iUniverse and published her book, Still Alice, herself.